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    The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. CONSENT - Comparison of metf Ormin XR to IR as mo Notherapy in the Newly diagno Sed Type 2 diab Etes Patients for the gastroi Ntestinal Tolerability and Efficacy: a Randomized, Parallel Control, Open-label and Multicenter Study Subjects will receive Metformin Immediate Release (IR) tablets, orally once daily at a dose of 500 milligram (mg) for 1 week, and then dose will increase with increments of 500 mg every week in first 2 weeks to 1500 mg. Listing a study does not mean it has been evaluated by the U. After that dose will increase up to maximum dose of 2000 mg for the next 2 weeks and will be maintained at 2000 mg until Week 16. This is a Phase 4, prospective, open label, randomized, parallel controlled multicenter trial in which metformin extended release (XR) will be compared with metformin immediate release (IR) for the gastrointestinal tolerability and efficacy in the newly diagnosed subjects with Type 2 diabetes who have glycosylated hemoglobin (Hb A1c) value between 7.0 to 10.0 percent (%). Subjects will receive Metformin Extended Release (XR) tablets, orally once daily at a dose of 500 mg for 1 week, and then dose will increase with increments of 500 mg every week in first 2 weeks to 1500 mg. After that dose will increase up to maximum dose of 2000 mg for the next 2 weeks and will be maintained at 2000 mg until Week 16. Janumet XR is an extended-release oral antidiabetic drug that helps to lower blood sugar levels in adults with type 2 diabetes. Each tablets contains two prescription medicines, sitagliptin and extended-release metformin. Janumet XR is used together with a healthy diet and regular exercise to help control blood sugar levels throughout the day in adults with type 2 diabetes. Janumet XR lowers your blood sugar levels throughout the day, even after meals, by helping your body produce more insulin, aiding your body to more effectively utilize the insulin your pancreas makes, and also by decreasing the amount of sugar that your liver produces. Every tablet of Janumet XR contains a combination of two antidiabetic drugs, sitagliptin and extended-release metformin. They both work together to help you better regulate your blood sugar levels. Sitagliptin belongs to a group of medicines called DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors), which break down digestive hormones in response to a meal.

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