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ESTRACE® CREAM estradiol vaginal cream, USP, 0.01% for vaginal dryness, itching, and burning in or around the vagina due to menopause. See full. Estrace (Estrofem) on IVFPharmacy is made by Novo Nordisk Pharmaceuticals. The drug composition is exactly the same as Estrace in the US but the packaging may vary slightly. Here's how: US packaging: Estrace (Estrofem) is supplied in different quantities depending on the strength and type of box you buy. Estrace 1mg can be purchased in boxes of 10, 30 or 45. Estrace 2mg can be purchased in boxes of 30, 50 or 90. These symptoms are often caused by vulvar and vaginal atrophy (VVA). VVA is a condition caused by the loss of estrogen due to menopause—a tissue issue. While lubricants may help with the symptoms of mild VVA, they can't treat the underlying cause. 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