Please review the following URL and make sure that it is spelled correctly. Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Chloroquine high Plaquenil erosive arthritis Plaquenil and acid refux Does plaquenil curb appetite In 2003, a novel mechanism was described wherein hydroxychloroquine inhibits stimulation of the toll-like receptor TLR 9 family receptors. TLRs are cellular receptors for microbial products that induce inflammatory responses through activation of the innate immune system. It is not well understood how Plaquenil helps treat autoimmune diseases like lupus and many types of arthritis. It is thought that Plaquenil interferes with how cells in the immune system communicate with each other. A comprehensive guide to side effects including common and rare side effects when taking Plaquenil Hydroxychloroquine includes uses, warnings, and drug interactions. Drugs A-Z Pill Identifier Supplements Symptom Checker Diseases Dictionary Media;. Immune system disorders Urticaria, angioedema, bronchospasm. It may prevent joint damage and reduce the risk of long-term disability. It can decrease the pain and swelling of arthritis. Plaquenil immune system Effects of Hydroxychloroquine on Immune Activation and., Plaquenil – RheumInfo Plaquenil and anxiety It alters your immune system, but as far as I know, it doesn't actually suppress it. Plus, if you have only been on it a month, it's probably not built up enough in your body to have much of an effect. I have actually been way HEALTHIER than ever since being on Plaquenil AND Methotrexate, which DOES suppress the immune system - go figure! Does Plaquenil supress the immune system?. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Any one have any experience or info regarding pre-existing precancerous conditions and the effects of Plaquenil on the immune system. I see so much info on the net where some says that Plaquenil has very mild effect on immune system except for eye issues --- Other info says it is an immunosuppressant. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. There is evidence that hydroxychloroquine may interfere with communication between cells in the immune system. This action suppresses the normally overactive immune response in lupus patients which may explain one reason Plaquenil works so well for those suffering with lupus.