Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil pregnan Hydroxychloroquine retinopathy an emerging problem Hydroxychloroquine has, on rare occasions, caused toxic psychosis when used for the treatment of discoid lupus. 19 Prolonged mepacrine therapy may produce a yellow discoloration of the skin and urine. Hepatitis and aplastic anemia have also been reported. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine is the drug of choice when a systemic agent is needed for discoid lupus erythematosus DLE. Chloroquine is second-line antimalarial therapy. Chloroquine and hydroxychloroquine should not be used in combination due to the increased risk of ocular toxicity. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Hydroxychloroquine discoid lupus Lupus Medications and Treatments, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Chloroquine acidic environmentPlaquenil cause muscle painPlaquenil poisoningDo i need hydroxychloroquine with methotrexatePlaquenil adverse effects Discoid lupus erythematosus is the most common type of chronic cutaneous lupus, an autoimmune skin condition on the lupus erythematosus spectrum of illnesses. It presents with red, inflamed, coin-shaped patches of skin with a scaling and crusty appearance, most often on the scalp, cheeks, and ears. Hair loss may occur if the lesions are on the scalp. The lesions can then develop severe scarring, and the centre areas may appear lighter in color with a rim darker than the normal skin. These lesion Discoid lupus erythematosus - Wikipedia. Discoid Lupus Erythematosus Medication Antimalarial.. Hydroxychloroquine Uses, Dosage & Side Effects -. Rheumatoid Arthritis. The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. Plaquenil is most known for its original purpose treating and preventing malaria. Malaria is a disease caused by parasites that can enter the body through a mosquito bite. The essential ingredient, known as quinine, is derived from the bark of the cinchona plant. Discoid lupus erythematosus DLE is a common canine autoimmune disease that usually manifests as a localized ulcerative and scarring nasal dermatitis. We report herein a generalized variant of canine DLE successfully treated with the antimalarial immunomodulator hydroxychloroquine HCQ.