She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. Plaquenil generic vs name brand Lpp plaquenil Hydroxychloroquine synthesis Our patient demonstrates the importance of using the new recommended screening tools for the detection of early hydroxychloroquine toxicity. 10-2 HVF, SD-OCT, autofluorescence, or mfERG might have detected the hydroxychloroquine retinal toxicity on the day of her presenting symptoms and possibly earlier, potentially limiting the amount of visual loss. Download Citation SD-OCT As screening test for hydroxychloroquine retinopathy The flying saucer sign Two asymptomatic women treated with hydroxychloroquine 200mg every day for 8 and 16. Figure 1 The flying saucer sign representing compromise of the perifoveal retinal tissue with maintenance of the foveal retinal tissue. From Chen E, Brown DM, Benz MS, et al. Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy the “flying saucer” sign. Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Plaquenil oct flying saucer Plaquenil Toxicity OS OCT - Retina Image Bank, SD-OCT As screening test for hydroxychloroquine retinopathy. Plaquenil retinal screening intervalAssay of chloroquine phosphatePlaquenil reviews rheumatoid arthritisChloroquine phosphate fish dosage dmorty Rx Side Effects New Plaquenil Guidelines and More ; Ophthalmic Pearls. Rx Side Effects New Plaquenil Guidelines and More. to the Academy’s revision of its recommendations on screening for retinal toxicity from chloroquine and its analogue hydroxychloroquine. He added that older time domain OCT units lack enough sensitivity for. Rx Side Effects New Plaquenil Guidelines and More.. Hydroxchloroquine and Chloroquine Toxicity - Eye Lessons. Hydroxychloroquine toxicity - EyeWiki. With Plaquenil Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 400 mg of Plaquenil daily puts anyone under 135 pounds at a higher risk for toxicity Therefore, 200mg of Plaquenil daily is going to be a safe dosage for virtually all adults13 In the five patients with SD OCT abnormalities, 3 had signs of early HCQ retinopathy while 2 had advanced changes. The “flying saucer” sign was present in all three of the five patients who presented with early HCQ retinopathy. Two patients presented with advanced HCQ retinopathy and moderate to severe vision loss. SD-OCT is capable of detecting characteristic macular changes of HCQ toxicity. These typical macular abnormalities include loss of the parafoveal ellipsoid zone EZ, parafoveal thinning of the outer nuclear layer ONL and inner plexiform layer IPL, the “flying saucer” sign, and peripapillary nerve fiber layer thinning 12 – 14.