Leflunomide, sulfasalazine, and hydroxychloroquine are effective therapies in RA and are commonly employed in combination therapy. Although the precise mechanisms of action of the traditional DMARDs are incompletely understood, most have both anti-inflammatory and immunomodulatory actions. Plaquenil dosage for sjogrens Apo hydroxychloroquine 200 mg Sigma chloroquine diphosphatase Indocin and plaquenil Does Leflunomide Interact with other Medications? Severe Interactions. These medications are not usually taken together. Consult your healthcare professional e.g. doctor or pharmacist for more. Combination Therapy for Rheumatoid Arthritis. It can be used with another drug in its class such as hydroxychloroquine, leflunomide, and sulfasalazine or with a biologic drug. This study evaluates the efficacy of the combination of methotrexate and hydroxychloroquine against leflunomide, a new DMARD as initial therapy in severe active rheumatoid arthritis. Hydroxychloroquine is known to increase the potency of methotrexate as well as increase its safety profile and reduce the dose. Toxicity from DMARD therapy can cause significant morbidity and rarely mortality; thus, appropriate dosing and monitoring for toxicity are essential. Choice of DMARD therapy should be tailored to the individual patient, with attention given to age, fertility plans, concomitant medications, and comorbidities. Leflunomide hydroxychloroquine combination Leflunomide-hydroxychloroquine combo shows promise in primary Sjögren’s., Treating Rheumatoid Arthritis Combination Therapy Hydroxychlor plaquenilChloroquine aralenVisual field plaquenil The study is based on leflunomide and hydroxychloroquine sulfate the active ingredients of Arava and Plaquenil, respectively, and Arava and Plaquenil the brand names. Other drugs that have the same active ingredients e.g. generic drugs are not considered. Arava and Plaquenil drug interactions - eHealthMe. Evaluation of efficacy of combination of methotrexate and.. Additive immunosuppressive effect of leflunomide and hydroxychloroquine.. Background/Purpose The combination of methotrexate MTX, sulfasalazine SSZ and hydroxychloroquine HCQ triple therapy is a highly effective and well-tolerated treatment in rheumatoid arthritis RA. While MTX is the cornerstone of most successful combination therapies, not all patients are candidates for, or tolerate, MTX. Leflunomide, a disease-modifying anti-rheumatic drug DMARD. Early, aggressive disease management is critical for halting disease progression and joint destruction in patients with rheumatoid arthritis. Combination therapy with at least two disease-modifying antirheumatic drugs, such as methotrexate MTX, sulfasalazine, or hydroxychloroquine, is often more effective than monotherapy in reducing disease activity. Traditional DMARDs Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies Amy C. Cannella, James R. O’dell Key Points Methotrexate is one of the most durable and frequently used disease-modifying antirheumatic drugs DMARDs in monotherapy as well as the cornerstone of combination therapy for rheumatoid arthritis RA.