Additionally, another exception occurred while executing the custom error page for the first exception. Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Plaquenil while taking maltac Skin discoloration plaquenil Synthesis of chloroquine from 4 7-dichloroquinoline Chloroquine retinopathy guidelines Humphrey Visual Field 10-2 Testing demonstrates a paracentral scotoma which is consistent with this macular toxicity that occurs with Plaquenil This patient was diagnosed with macular toxicity, secondary to plaquenil use. She was educated to discontinue plaquenil and is following up with a retina specialist. The main outcomes were toxicity as determined by characteristic visual field loss or retinal thinning and photoreceptor damage. They also examined risk factors and prevalence. The study findings revealed that when hydroxychloroquine was used at doses 5mg /kg, the risk of retinopathy was 1% in the first 5 yrs. 2% in 10 yrs. 20 % after 20 yrs. Peripheral retina was unremarkable OU. Fundus photos, visual field 10-2 were ordered as well as a spectral domain ocular coherence tomography SD-OCT see Figures 1-3. The appearance of disruption of the photoreceptor integrity line, perifoveal thinning, and paracentral scotomas confirmed a high likelihood of toxicity in this patient. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. Plaquenil toxicity 10-2 Plaquenil Toxicity - Bennett & Bloom Eye Centers, My Take on New Ocular Screening Guidelines for Plaquenil. Plaquenil and plaque in arteries Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Plaquenil Side Effects Common, Severe, Long Term -. Determine risk for hydroxychloroquine retinal toxicity.. Retinal toxicity associated with chronic exposure to.. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. Although it is considered rare, retinal toxicity from the intake of Plaquenil can be irreversible even if the drug is discontinued 2, 3. What is Plaquenil Toxicity? The toxicity resulting from the intake of Plaquenil is due to its affinity for melanin-containing structures in the body. This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative.