I did stop it for 2 weeks early in the treatment due to having to take a coupld other drugs that seemed to give me side effects. I just quit the plaquenil to give my liver a rest at that time. Plaquenil isn a antiparasitic drug with anti-inflammatory affect. Hydroxychloroquine public assessment report Plaquenil immune system What does plaquenil do for you Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. If side effects do occur, they are usually minor and last only for a short period of time. Potential side effects of anti-malarial drugs include Skin rashes and pigment change. Atabrine, specifically, can cause yellow pigmentation of skin. Sometimes Plaquenil can also deposit in the tissues of the body and cause the skin to take on a greenish tone. I recently decided to stop taking Plaquenil because I was having constant chest pains even more so than I usually have due to Lupus. Since I have not taken it my chest feels so much better which is odd because chest pain is not listed as a side effect. Also I noticed that the Plaquenil I think was making me feel different but not in a good way. Over the years on this site we have had quite a few people post that they didn't think that the plaquenil was working so they would stop taking it. I have done a lot of research on this drug and haven't run into anybody who has complained of the withdrawal effect. What to expect when taking plaquenil for the first time Hydroxychloroquine – what you can expect when starting., Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus Center Plaquenil long term side effects I fully expect to be throwing up as I have to take 8 ml. Luckily I can take it with food apparently but there is no way that anything will be able to disguise that taste. I do manage to take my warfarin tablets with food and am now wondering whether plaquenil tablets are a similar size to warfarin or not, and if they can be taken with food. Plaquenil info please I have now. - Sticky Blood-Hugh.. Had to stop taking Plaquenil -. Plaquenil Side Effects Common, Severe, Long Term -. The Plaquenil is supposed to kick in in 3 to 6 months. I think it was 8 months for me. One day I was congratulating myself for getting so many things done and I realised that the days had been getting better without my noticing. Plaquenil received an overall rating of 5 out of 10 stars from 4 reviews. See what others have said about Plaquenil, including the effectiveness, ease of use and side effects. Hello all, I am currently new to this site and ran across the discussion about stopping Plaquenil. I have been taking Plaquenil for about 8-9 months and thought that it was not helping me because I still have a fair amount of joint pain, fatigue, muscle pain and so many other issues.