Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take hydroxychloroquine with all of your drugs and health problems. Chloroquine interaction Hydroxychloroquine medlineplus Imuran or methotrexate zmombomb I saw the Rheumy yesterday, and she was happy for me that Plaquenil is working on my pain, and upset that no other doctor had bothered to treat me with the Plaquenil in the past 9 years, then said that I will most likely need methotrexate or imuran, as I still have inflammation in my joints. Our Imuran azathioprine Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Common Side Effects of Plaquenil. Tell your doctor if any of the following side effects, as they may be indications of a more serious reaction Headache; Loss of appetite; Dizziness; Nausea For all uses of hydroxychloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Plaquenil and imuran heat and sun side effects Rheumatoid Arthritis Treatment Options Johns Hopkins., Side Effects of Imuran Azathioprine, Warnings, Uses Plaquenil and trintellix interactions RARE side effects. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. Common and Rare Side Effects for Plaquenil Oral. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Stopping Plaquenil - General Discussion - Life With Lupus. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have had any eye changes or changes in eyesight due to hydroxychloroquine or drugs like this one. If you have psoriasis. The plaquenil has helped with my sun sensitivity, fatigue and rashes. I get 2-3 eye exams a year and the time they suspected build up I was taken off it for 1 1/2. I get 2-3 eye exams a year and the time they suspected build up I was taken off it for 1 1/2. Hi All, I've been on plaquenil for a couple of months now and it is definitely affecting my tolerance to the sun. I burn more easily which I didn't think was possible since I am extremely fair and already have to be very sun smart and am starting to get rashes after sun exposure.