These drugs are called disease-modifying antirheumatic drugs (DMARDs), and they are an important part of an overall treatment plan. Disease-modifying drugs act on the immune system to slow the progression of rheumatoid arthritis. This is why they are called "disease-modifying." Many different drugs can be used as DMARDs in the treatment of RA, but some are used more often than others. Hydroxychloroquine otc Retina doctors westport ct plaquenil Oct 29, 2013 Triple therapy refers to a combination of three non-biologic DMARDs, most frequently sulfasalazine, hydroxychloroquine, and methotrexate. Other DMARDs can be used based on what medications patients can tolerate. Hydroxychloroquine is an antimalarial drug which is relatively safe and well-tolerated agent for the treatment of rheumatoid arthritis. Chloroquine is another antimalarial agent that is also sometimes used. Triple therapy refers to a combination of three non-biologic DMARDs, most frequently sulfasalazine, hydroxychloroquine, and methotrexate. Other DMARDs can be used based on what medications patients can tolerate. They are not as powerful as other DMARDs, but they usually cause fewer side effects. Hydroxychloroquine (Plaquenil) and sulfasalazine (Azulfidine) are used for mild rheumatoid arthritis. Abatacept sulfasalazine hydroxychloroquine triple therapy Hydroxychloroquine Uses, Dosage & Side Effects -, Rheumatoid Arthritis Treatment Options Johns Hopkins. Avloclor 250mg chloroquine phosphateTylenol plaquenil Methotrexate-inadequate response In patients with an inadequate response to methotrexate, several treatments were statistically significantly superior to oral methotrexate for ACR50 response triple therapy moderate quality evidence, methotrexate + hydroxychloroquine low quality evidence, methotrexate + leflunomide moderate quality evidence, methotrexate + intramuscular gold very low quality evidence, methotrexate + most biologics moderate to high quality evidence, and. Methotrexate alone or in combination with other medications.. Triple Therapy / Combination Therapy for Rheumatoid.. What are the risks vs. benefits of biologic therapy.. Apr 04, 2016 Triple therapy, which consists of three well-established DMARDs sulfasalazine a sulfa drug, hydroxychloroquine Plaquenil, and methotrexate, was shown to have comparable benefits to a combination biologic/methotrexate therapy. The first-line agent should be metho- trexate MTX, with leflunomide, sulfasalazine, or hydroxychloroquine as an alternative. If monotherapy is not sufficient to reach the target goal, triple therapy or MTX plus a tumor necrosis factor-alpha TNF-alpha inhibitor should be considered. Among methotrexate-naive patients, methotrexate + sulfasalazine + hydroxychloroquine “triple therapy”, methotrexate + several biologics abatacept, adalimumab, etanercept, infliximab.