Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil trouble swallowing Will plaquenil take joint swelling away Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Hydroxychloroquine oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Carbamazepine interaction hydroxychloroquine Network-based approach to prediction and population-based validation of., Hydroxychloroquine Side Effects, Dosage, Uses, and More Folic acid and hydroxychloroquine dosingPlaquenil rheumatoid arthritis renalNorth star pharmaceuticals makers of hydroxychloroquine Digoxin, cyclosporine, and certain beta blockers may cause drug interactions with hydroxychloroquine. This eMedTV segment explores what may happen if these drugs are taken with hydroxychloroquine and lists other drugs that may cause an interaction. Drug Interactions With Hydroxychloroquine. Hydroxychloroquine Side Effects Common, Severe, Long Term -. Plaquenil Oral Interactions with Other Medication. Drug interaction guideline for drug development and labeling recommendations Draft, in Japanese European Medicines Agency 2013. Guideline on the Investigation of Drug Interactions. In our case, no carbamazepine‐related cardiac findings were detected. Despite the fact that the level of carbamazepine was within the normal range and the clinical situation was appropriate for discharge at the 3rd day of follow‐up, the patient continued to follow for thrombocytopenia and could be discharged on the 4th day. What are some other side effects of Hydroxychloroquine? All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away Dizziness. Headache. Feeling nervous and excitable.