In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Medication reaction to plaquenil Photopsia plaquenil toxicity Hydroxychloroquine patient teaching Use of this drug is contraindicated 1 in the presence of retinal or visual field changes attributable to any 4-aminoquinoline compound, 2 in patients with known hypersensitivity to 4-aminoquinoline compounds, and 3 for long-term therapy in children. Oct 12, 2019 Looking for subtle retinal changes. Hydroxychloroquine is commonly used to treat autoimmune inflammatory diseases such as rheumatoid arthritis. A rare side effect is retinal toxicity, which can cause irreversible and progressive vision loss. Ocular side effects of hydroxychloroquine can include impact on the cornea, ciliary body, lens and retina. 1 Corneal deposits, fortunately, rarely affect vison. 2 However, the concern of retinal toxicity and the need for monitoring must be reviewed with patients prior to and during its use. 2,3 You Might Also Like As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Retinal changes with the use of hydroxychloroquine Retinal Physician - Hydroxychloroquine Maculopathy An., Novel Image Analysis Platform May Detect Early Signs of. Plaquenil toll like endosomalPlaquenil infoPrice hydroxychloroquine 200 mg Mar 18, 2016 The researchers observed no significant differences or change in measurements of inner retinal thickness in different retinal regions between short- and long-term hydroxychloroquine users 27 patients, and during a median follow-up of 39 months 15 patients. Is Retina Thickness Affected by Hydroxchloroquine? - MPR. Ocular Disease Monitoring Critical to Avoid Retinal Toxicity.. LONGITUDINAL CHANGES IN EYES WITH HYDROXYCHLOROQUINE.. On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful. Sep 13, 2019 Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Significant risk factors for retinal damage include daily doses of hydroxychloroquine sulfate greater than 6.5 mg/kg 5 mg/kg base of actual body weight, durations of use greater than five years.