Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Areas with chloroquine or mefloquine resistance Does hydroxychloroquine lower immune system Plaquenil ocular screening The mechanisms of action of hydroxychloroquine and chloroquine remain under continuous study in modern molecular medicine 17,18 using advanced tools in computational biology 19, synthetic biology. Mechanism of action Plaquenil increases the pH of lysosomes and impairs complement-dependent antigen-antibody reactions. It also inhibits the chemotaxis of eosinophils and locomotion of neutrophils. Hydroxychloroquine is an antimalarial agent that has been used in systemic lupus erythematosus and rheumatoid arthritis treatment for many years. Recently, novel mechanisms of action have been proposed, thereby broadening the therapeutic perspective of this medication. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Mechanism plaquenil PLAQUENIL®, Hydroxychloroquine Plaquenil RheumTutor Lyme and plaquenilCan long-term use of plaquenil causing low-blood sugarHydroxychloroquine side effects kidneyMoa chloroquine malaria Mechanism of action. Hydroxychloroquine increases lysosomal pH in antigen-presenting cells. In inflammatory conditions, it blocks toll-like receptors on plasmacytoid dendritic cells PDCs. citation needed Hydroxychloroquine, by decreasing TLR signaling, reduces the activation of dendritic cells and the inflammatory process. Hydroxychloroquine - Wikipedia. Hydroxychloroquine decreases Th17-related cytokines in.. Plaquenil hydroxychloroquine sulfate dosing, indications.. What is hydroxychloroquine Plaquenil, and how does it work mechanism of action? Hydroxychloroquine is classified as an anti-malarial drug. It is similar to chloroquine Aralen and is useful in treating several forms of malaria as well as lupus erythematosus and rheumatoid arthritis. Jan 01, 2020 Mechanism of action The mechanisms underlying the anti-inflammatory and immunomodulatory effects of Plaquenil are unknown. Indications and Usage for Plaquenil Malaria. Plaquenil is indicated for the treatment of uncomplicated malaria due to P. falciparum, P. malariae, P. ovale, and P. vivax. The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus. These compounds lead to improvement of clinical and laboratory parameters, but their slow onset of action distinguishes them from glucocorticoids and nonsteroidal antiinflammatory agents.