Mechanism of chloroquine resistance

Discussion in 'Chloroquine 250' started by vladwww, 09-Mar-2020.

  1. Sc4ndy User

    Mechanism of chloroquine resistance


    Resistance to currently available antimalarial drugs has been confirmed in only two of the four human malaria parasite species, first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.

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    Causes of resistance 12 3.1 Definition of antimalarial drug resistance 12 3.2 Malaria treatment failure 12 3.3 Mechanisms of antimalarial resistance 12 3.3.1 Chloroquine resistance 12 3.3.2 Antifolate combination drugs 13 3.3.3 Atovaquone 13 3.4 Factors contributing to the spread of resistance 13 3.4.1 Biological influences on resistance 13 Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain.

    Although resistance to these drugs tends to be much less widespread geographically, in some areas of the world, the impact of multi-drug resistant malaria can be extensive. Has also developed resistance to nearly all of the other currently available antimalarial drugs, such as sulfadoxine/pyrimethamine, mefloquine, halofantrine, and quinine.

    Mechanism of chloroquine resistance

    Aralen Chloroquine Uses, Dosage, Side Effects., Drug Resistance in the Malaria-Endemic World - CDC

  2. Chloroquine invented
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  4. Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. Whether the protein mediates extrusion.

    • On the Mechanism of Chloroquine Resistance in Plasmodium..
    • Chloroquine - FDA prescribing information, side effects..
    • Chloroquine – howMed.

    The spread of chloroquine resistance poses a serious challenge to find strategies to treat malaria. an understanding of the molecular mechanisms involved in chloroquine resistance can lead to. Oct 01, 2018 Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. Recently, an altered chloroquine-transporter protein CG2 of the parasite has been related to chloroquine resistance, but other mechanisms of resistance also appear to be involved. Research on the mechanism of chloroquine and how the parasite has acquired chloroquine resistance is still ongoing, as other mechanisms of resistance are likely.

     
  5. SERG36 XenForo Moderator

    This article focuses upon hydroxychloroquine retinopathy. Chloroquine was originally used as an anti-malarial therapeutic. AAO Guidelines for Chloroquine Screening Hydroxychloroquine usage in US patients, their experiences of. Plaquenil Guidelines Point Out New Risks, New Presentation.
     
  6. ooomagnat User

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Management of Fibromyalgia Syndrome Review of Evidence Healthboards - Immune & Autoimmune - Fibromyalgia plaquenil Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.
     
  7. ladyinet New Member

    Hydroxychloroquine Price Comparison Uses, Dosage, Form. Prices of the drug can vary in different shops. There will be a variation in price from pharmacy to an online shop. Most online shops will have a little lower price when compared to pharmacy stores, so you need to cross check before buying.

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