Instead of only targeting bad things like viruses and bacteria, it also attacks healthy cells and tissues. Most likely they will show up every now and then, or in what your doctor might call “flares.” Your symptoms will often get worse and then get better. Colchicine and hydroxychloroquine Psoriasis and plaquenil Turned out to be nothing. I forget exactly how they said it but it was just the tissue of the lymph node was enlarged I guess. Not sure what your situation is but I have lupus and take plaquenil and it is working perfectly for me. I guess sometimes lymph nodes are just reactive and it doesn’t often mean something bad is happening. Unexplained fever, weight loss, night sweats, and/or swollen lymph nodes should raise a high level of suspicion for lymphoma and warrant an immediate workup to assess for infection, malignancy, or any new-onset autoimmune disorders. Additionally, when lymphoma or cancer is discovered, patients should follow the therapy outlined by their oncologist. Doctors give trusted, helpful answers on causes, diagnosis, symptoms, treatment, and more Dr. Legha on can lupus cause swollen lymph nodes Lymph nodes enlarge as a reaction to inflammation so if the skin inflammation is significant then enlargement can occur. Always tell your doctor of any new symptoms you are having. Some could totally go away, but others might not improve at all. Can plaquenil cause swollen lymph nodes Hydroxychloroquine Sulfate Lymphadenopathy Reports., Lymphoma in Patients With Systemic Lupus Erythematosus. Hydroxychloroquine dosesWolpin oncologist 2014 hydroxychloroquine There is no Swollen glands reported by people who take Plaquenil yet. This review analyzes which people have Swollen glands with Plaquenil. It is created by eHealthMe based on reports from Food and Drug Administration FDA, and is updated regularly. eHealthMe has been monitoring drugs and supplements since 2008. Will you have Swollen glands with Plaquenil - eHealthMe. Can lupus cause swollen lymph nodes - What You Need to Know. Hydroxychloroquine Sulfate Lymphadenopathy Reports - DrugInformer. There can be many reasons for swollen lymph nodes. But it appears that lymphadenopathy could be common with autoimmune diseases and that makes sense given the fact that the lymph nodes are part of the immune system. If you find swollen or painful lymph nodes, please speak to your doctor about this symptom. As for the symptoms I suffer from Lupus, I have joint pain and swelling, muscle aches, fatigue, a red rash across my cheeks and the bridge of my nose, my forehead is often broke out, I am losing hair I think Plaquenil might be the culprit there, occasional swollen lymph nodes under my arms and behind my knees usually in flares. When you have lupus, something happens to your body’s natural defense system your immune system to make it work incorrectly. Instead of only targeting bad things like viruses and bacteria, it also attacks healthy cells and tissues. There are several types of lupus, and every case is different.