Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases (but not all), likewise silica, aromatic and chlorinated solvents, ketones, trichloroethylene, welding fumes and white spirits exposure seems to contribute to the condition in a small proportion of affected persons. Vitamin D is implicated in the pathophysiology of the disease. Macrobid and plaquenil Chloroquine prostate cancer Biaxin and plaquenil lyme disease Drug-Induced Skin Itching Plaquenil, Minocycline, Many Others. Many medications can cause itching as either a minor or major side effect. Scleroderma patients, in particular, should never assume that itching is caused just by the disease. This section of the Scleroderma FAQ is focused on standard treatment approaches that are designed either to target the overall disease process or to modify the disease in a way that can potentially improve more than one symptom, for example, bosentan Tracleer for skin ulcers and PAH. Scleroderma is a chronic disease that causes the skin to become thick and hard, a buildup of scar tissue, and damage to internal organs such as the heart and blood vessels, lungs, stomach and kidneys. Typical scleroderma is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes and antinuclear antibodies. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune system. Scleroderma plaquenil Scleroderma - Wikipedia, Scleroderma Treatment General – Standard - Scleroderma. How to taper off plaquenil Hi Vanessa, My son was put on Plaquenil 9 months after being diagnosised with sine scleroderma. At the time, he had esophageal dysmotility 2/3rds of his esophagus, positive ANA, + Anti-RNA Polymerase 1/111, severe fatigue, and tightening of the chest cavity chondro. Plaquenil pros and cons - Sclero Forums MAIN - Sclero Forums. Scleroderma -. COVID-19 and scleroderma scleroderma. Anti-malarial drugs, such as Plaquenil hydroxychloroquine, is often used to manage lupus and can also be effective in scleroderma. Plaquenil is thought to interfere with communication between immune cells, which can suppress the damaging effect of an overly active immune response without raising a patient’s risk of susceptibility to infections. Scleroderma sklair-oh-DUR-muh is a group of rare diseases that involve the hardening and tightening of the skin and connective tissues. Scleroderma affects women more often than men and most commonly occurs between the ages of 30 and 50. While there is no cure for scleroderma, a variety of treatments can ease symptoms and improve quality of life. This is a reivew of how effective Plaquenil hydroxychloroquine sulfate is for Systemic sclerosis scleroderma and for what kind of people. The study is created by eHealthMe from 11 Plaquenil users and is updated continuously.