In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Plaquenil side effects during pregnancy Is chloroquine safe in first trimester of pregnancy The risk of a toxicity sharply increases after 5 years, with majority of cases of retinotoxicity occurring in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine Plaquenil. This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day 200 bid. Hydroxychloroquine can cause irreversible retinal toxicity, resulting in bilateral bull’s eye retinopathy, but is regarded as less toxic to the retina than chloroquine and it does not cause the corneal deposits seen with chloroquine therapy. End stage hydroxychloroquine toxicity leads to widespread RPE and retinal atrophy with a loss of central vision, peripheral vision, and night vision. Recent studies have shown that patients of Asian descent develop initial damage in a more peripheral extramacular distribution near the arcades, most frequently in the inferotemporal region with corresponding superonasal field defects. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Hydroxychloroquine poisoning Chloroquine and Hydroxychloroquine • LITFL • Toxicology., Hydroxychloroquine DermNet NZ Is plaquenil for painChloroquine vs hydroxychloroquine autophagyHow does hydroxychloroquine work for arthritisHydroxychloroquine and supporting supplements Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Hydroxychloroquine Plaquenil Toxicity and.. Hydroxychloroquine Uses, Dosage & Side Effects -. Sep 15, 2014 Hydroxychloroquine sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions, with less toxic effects than chloroquine. Hydroxychloroquine-Induced Retinal Toxicity Symptoms and Signs. Patients in earlier stages of hydroxychloroquine retinal toxicity usually do not. Mechanism of Toxicity. The mechanism of hydroxychloroquine retinal toxicity has yet. Medication Dosage. Several factors have been associated with. Lyons emphasizes the importance of annual screening and says that, although annual screening is recommended for everyone taking Plaquenil, it is imperative for people who have been taking the medication for more than 10 years, who have a higher incidence of retinal toxicity.