Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine overdose death Does plaquenil reduce fevers Chloroquine target life cycle I had been taking plaquenil since April for my lupus and sjogrens. It was working really well and just recently my rheumy told that I was in remission. I felt great. Then I had an allergic reaction to the plaquenil - a rash all over my body, neck, arms and legs. I stopped taking it 1 week ago. Sep 13, 2019 Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil skin rash pictures Ask the Expert Plaquenil and Sjögren’s, Plaquenil Side Effects Common, Severe, Long Term - Plaquenil lupus Background Hydroxychloroquine sulfate and other antimalarial drugs have been used successfully as adjunctive therapy for patients with cutaneous lesions of dermatomyositis over the past 20 years. An increased incidence of cutaneous reactions to hydroxychloroquine has been postulated to occur. Adverse Cutaneous Reactions to Hydroxychloroquine Are More.. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Plaquenil has beneficial effects on 3 major aspects of lupus; skin rashes, aches & pains and fatigue. It has also been found to help in a number of other features of the disease, though less predictably. It is very effective in the treatment of a whole variety of lupus skin rashes, particularly those found to be worsened by sunlight. Skin conditions associated with lupus are fairly significant and a major marker of the disease. Of the eleven criteria set by the American College of Rheumatology for a diagnosis of lupus, four are skin-related. These include Malar rash - “butterfly rash” that appears on the cheeks; Discoid rash - red patches on the skin that can lead to. I wonder if the commencement of the skin rashes and itching is related in some way to this decreased effectiveness of the medication too. So far from the other posts it may seems that Plaquenil may be somehow associated with skin rash that looks like small hives and patchy itchiness.