One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Does plaquenil cause depression Stopping plaquenil Chloroquine overdose death Side effects hydroxychloroquine plaquenil Practice Essentials. Chloroquine and hydroxychloroquine belong to the quinolone family. Although their therapeutic and toxic doses differ, they are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity. The image below depicts hydroxychloroquine retinopathy. In fact, the aPL 1st may contribute to the pathogenesis of premature atherosclerosis in SLE, but 2nd they are also the serologic markers of APS, and therefore, of Hughes’ retinopathy. Figure 1 illustrates better the relationships between the most important mechanisms of retinopathy in SLE. Plaquenil or hydroxychloroquine is under the quinolone family. These medications are initially used in the prophylaxis and treatment of malaria. Plaquenil has replaced chloroquine because it produces less retinal side effects. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil retinopathy pathogenesis Diabetic retinopathy pathogenesis, clinical grading., Retinopathy in systemic lupus erythematosus pathogenesis and. Hydroxychloroquine human antichimeric antibodiesPlaquenil toxicity diagnosis codeAralen artritisHydroxychloroquine plaquenil and surgeryPlaquenil safer than floroquinolones Apr 10, 2019 Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil Uses, Dosage & Side Effects -. Plaquenil Toxicity - Symptoms, Treatment, Risk Factors.. Hydroxychloroquine Plaquenil Toxicity and Recommendations for Screening. Jan 05, 2020 Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported. This article focuses upon hydroxychloroquine retinopathy. Disease Ocular symptoms of retinopathy include blurred and partial loss of central vision, side vision and in the later stage, night vision. Symptoms of corneal deposits include haloes and glare. Clinical research has resulted in precise screening protocols and safe dosing guidelines to prevent ocular toxicity and detect retinal damage at an early stage. DR can be divided into 2 stages non-proliferative diabetic retinopathy NPDR and proliferative diabetic retinopathy PDR. NPDR can be further divided into mild, moderate, and severe stages. 1 In general, retinopathy advances from mild nonproliferative abnormalities, characterized by increased numbers of microaneurysms.