It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Does plaquenil affect your sleep Plaquenil and foot pain Yes, plaquenil can affect your liver. My doctor runs blood work at 6 month intervals to check on liver. I also get 6 month eye exams while on plaquenil. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine Plaquenil 200mg bid 6.5mg/kg for 10 years, which was stopped one year prior to presentation. For prolonged treatment of lupus or arthritis, adverse effects include the acute symptoms, plus altered eye pigmentation, acne, anaemia, bleaching of hair, blisters in mouth and eyes, blood disorders, convulsions, vision difficulties, diminished reflexes, emotional changes, excessive coloring of the skin, hearing loss, hives, itching, liver problems or liver failure, loss of hair, muscle paralysis, weakness or atrophy, nightmares, psoriasis, reading difficulties, tinnitus, skin inflammation and scaling, skin rash, vertigo, weight loss, and occasionally urinary incontinence. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. For short-term treatment of acute malaria, adverse effects can include abdominal cramps, diarrhea, heart problems, reduced appetite, headache, nausea and vomiting. Plaquenil and liver Protecting your eyesight when taking Plaquenil Lupus., Plaquenil Oral Uses, Side Effects, Interactions. Plaquenil lupus how long to workChloroquine clinical trials cancerChloroquine dose in pediatricsIs plaquenil used for mixed connectivity tissue disorderWhat is another name for hydroxychloroquine Liver Enzymes. Liver enzymes are present in liver cells and are spilled out into the bloodstream when there is an injury or illness to the liver. If you suffer from rheumatoid arthritis and are taking medication to treat your disease, you will be routinely tested for liver enzymes. Rheumatoid Arthritis & Elevated Liver Enzymes Healthfully. Hydroxychloroquine Plaquenil Toxicity and.. Hydroxychloroquine - LiverTox - NCBI Bookshelf. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. According to the Mayo Clinic. Hydroxychloroquine is a disease-modifying anti-rheumatic drug DMARD. It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. In these patients, high doses of hydroxychloroquine may trigger liver damage. 9, 10, 17 From the community “I was on Plaquenil for 5 1/2 yrs with no liver problems but had to stop it because it had started to affect my retinas.” - Inspire member “I take 200 mg of Plaquenil a day. I was told it can take months to help and it did.