See below for a comprehensive list of adverse effects. Applies to azathioprine: oral tablet Other dosage forms: Oral route (Tablet) Chronic immunosuppression with azathioprine increases risk of malignancy in humans. How does chloroquine prevent malaria Plaquenil sun pharmaceuticals 347 Chloroquine antibacterial activity Could you develop a rash 3 weeks after starting hydroxychloroquine Mast cell activation syndrome MCAS is a relatively recently recognized cause of chronic multisystem polymorbidity of a generally inflammatory theme. Patients with MCAS often report migratory soft tissue and/or bone pain which frequently responds poorly to typical narcotic and non-narcotic analgesics as well as atypical analgesics such as antidepressants and anticonvulsants. We report the efficacy of hydroxychloroquine in four patients with cutaneous mastocytosis n = 2 and mast cell activation syndrome n = 2. We show that this molecule reduces the long-term survival of primary human mast cells, interferes with lysosome function and leads to the accumulation of non-functional tryptase in the mast cell granules. Seems I have recently been diagnosed with Mastocytosis. I have had systemic Lupus for more that 15 years along with Sjogren's, ebstien barr virus and a few other things that follow lupus. Physicians using this drug should be very familiar with this risk as well as with the mutagenic potential to both men and women and with possible hematologic toxicities. Along with its needed effects, azathioprine (the active ingredient contained in Imuran) may cause some unwanted effects. Reports of malignancy include post-transplant lymphoma and hepatosplenic T-cell lymphoma (HSTCL) in patients with inflammatory bowel disease. Plaquenil mastocytosis Is MACROCYTOSIS a side effect of PLAQUENIL ?, Hydroxychloroquine as a novel therapeutic approach in mast cell. Chloroquine endosomeChloroquine virus productionChloroquine diphosphate sigmaDoi need to take prednisone with plaquenil Plaquenil and Macrocytosis - from FDA reports Summary Macrocytosis is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 10+ years, also take medication Methotrexate, and have Coronary heart disease. Will you have Macrocytosis with Plaquenil - eHealthMe. Lupus and Mastocytosis - Treato. Studies linking Sjogren's with Mastocytosis. Aug 27, 2014 I have been on Plaquenil for 4 years now, with the initial side effects a little stomach upset-take w/food having worn off in about 2 weeks, without that horrible pain or need for a dose increase. The only thing I need to do with Plaquenil is an eye exam every 6 months.check for changes in vision. Feb 22, 2018 Mast cells are a type of white blood cell in the immune system. Mast cells are responsible for protecting the body from infection and releasing chemicals to create inflammatory responses. The signs and symptoms of mastocytosis vary based on which parts of the body are affected. There are two main forms of mastocytosis. Alopecia has been reported in patients on azathioprine the active ingredient contained in Imuran monotherapy or in combination with other immunosuppressants. This side effect may resolve spontaneously despite ongoing therapy.