We report the case of a 65‐yr‐old woman who developed Stevens–Johnson syndrome 2 weeks after commencing treatment with hydroxychloroquine. Our patient had a 9‐yr history of rheumatoid arthritis with multiple episodes of relapse and remission. Figuring hydroxychloroquine dossage Plaquenil macular changes What eye exams do you need for plaquenil Mar 11, 2014 Malar rash. It takes time. Be patient. It is important that you always use sunscreen on this area and never to allow it to get sunburned. Additionally, consider seeing a dermatologist in another 5 weeks if the rash is not starting to get lighter. Even taking a picture and comparing every 4 weeks would give you a starting point. Read more. The time range between commencement of the new formulation of HCQ and the appearance of a rash was 1–30 days most reactions occurred in the first 1–2 weeks. Generally, the rash was mild and disappeared 1–3 weeks after the drug was stopped. Concomitant medications used by the patients are shown in Table 2. Within 2 weeks, whilst she was on holiday in Tenerife, she developed a pruritic rash over her abdomen, which she described as ‘targets’. She stopped the hydroxychloroquine but within 24 h the rash had become exfoliating, and she developed oral ulceration and hypotension. Over the course of her disease, she had been treated with prednisolone at doses ranging from 5 to 20 mg, but was intolerant of gold (diarrhoea), sulphasalazine (nausea and vomiting), penicillamine (proteinuria) and methotrexate (mouth ulcers, nausea and constipation). She also had a medical history of hypertension (treated with bendrofluazide). Could you develop a rash 3 weeks after starting hydroxychloroquine Plaquenil - I have started having a terrible rash/hives I don., Increased cutaneous reactions to hydroxychloroquine Plaquenil. Hydroxychloroquine stomach painPlaquenil and diabetic retinopathyHydroxychloroquine otcHydroxychloroquine and blood pressureWhat does plaquenil do Does anyone who has RA suffer with itchy skin taking Hydroxychloroquine. and then to develop side effects. a couple of weeks. I recently was told to start. Does anyone who has RA suffer with itchy skin taking. - NRAS. Stevens–Johnson syndrome in association with.. Plaquenil and itching -. While hydroxychloroquine is considered a relatively safe medication, like all medications there are potential risks. These include body rashes that often will itch. The rash typically occurs in the first 6 weeks and is usually mild. In general, the rash will resolve within 2 weeks after stopping the drug. Most other drugs can be taken safely with hydroxychloroquine. There are important interactions with Amiodarone and Digoxin taken for heart disease and with drugs used for epilepsy. However, if you start any new drugs, you should remind the doctor that you are already taking hydroxychloroquine. I have been taking plaquenil hydroxychloroquine for 3 weeks. A fine, red, non itchy rash has appeared on my back and chest. Is this a side effect that will go away? Flesh colored itchy rash on top of feet and inside ankle. I do take plaquenil hydroxychloroquine 400mg daily for ra. Havent changed soaps, detergents, etc.