While the mechanism is poorly understood, pregnant women have a reduced immune response and therefore less effectively clear malaria infections. In addition, malaria parasites sequester and replicate in the placenta. Is hydroxychloroquine antiviral Hydroxychloroquine and taltz for axspa Doxycycline. There is no evidence for human teratogenicity with doxycycline use during pregnancy. 8 Despite this, the main concern with doxycycline, like tetracycline, is the risk to the fetus of inhibition of bone growth and discoloration and dysplasia of the teeth, 3 which can occur during the period of calcification beyond the fourth month of gestational age. 4 Because of the potential harm. The purpose of this study is to test prevention strategies for pregnancy-related malaria. Researchers will compare different malaria treatments and treatment schedules which include chloroquine therapy weekly doses versus being dosed twice during pregnancy for 3 days each time to the standard practice of preventive treatment intervals in pregnancy with the drug sulfadoxine-pyrimethamine. There are no adequate and well-controlled studies evaluating the safety and efficacy of chloroquine in pregnant women. Usage of chloroquine during pregnancy should be avoided except in the suppression or treatment of malaria when in the judgment of the physician the benefit outweighs the potential risk to the fetus. REFERENCES. 1. Malaria infection during pregnancy can lead to miscarriage, premature delivery, low birth weight, congenital infection, and/or perinatal death. Pregnant women are three times more likely to develop severe disease than non-pregnant women acquiring infections from the same area. Chloroquine during early pregnancy Chloroquine Oral Uses, Side Effects, Interactions., Chloroquine for Malaria in Pregnancy - Full Text View. Skin splits on fingertips hydroxychloroquineChloroquine and anxiety Pregnancy and Chloroquine According to the Centers for Disease Control and Prevention CDC, chloroquine is considered safe to use during pregnancy. Tell your doctor if you're pregnant or might. Chloroquine Aralen - Side Effects, Dosage, Interactions.. Aralen Chloroquine Uses, Dosage, Side Effects.. Pregnancy Symptoms 15 Early Signs That You May Be Pregnant. Chloroquine has not been formally assigned to a pregnancy category by the FDA. There are no controlled data in human pregnancies. Congenital anomalies were reported in the offspring of one woman being treated with chloroquine 250 to 500 mg daily during pregnancy for SLE; however, chloroquine has been used in the prophylaxis and treatment of malaria during pregnancy without evidence of fetal harm. Pregnancy. There are no adequate and well-controlled studies evaluating the safety and efficacy of chloroquine in pregnant women; usage during pregnancy should be avoided except in prophylaxis or treatment of malaria when benefit outweighs potential risk to fetus. Lactation Chloroquine vs no prophylaxis. The prevention of malaria during early pregnancy relies on an integrated approach, including drug and antivectorial strategies and, possibly in the future, a pregnancy-associated malaria vaccine. Antivectorial Strategies.