Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine: Incidence not known Some side effects of chloroquine may occur that usually do not need medical attention. Hair loss plaquenil myositis Chloroquine apoptosis Hydroxychloroquine immunosuppressive Silver chloroquine By 2/2010 things were so dim I could not see to shop in stores. I quit taking Plaquenil but the DR still said no toxicity. My eyes continued to get worst. In tears I went back in July he finally sent me to a retina specialist. You don't have to have Bulls eye damage to have toxicity Over weight women over 60 should beware of taking Plaquenil. Chloroquine and hydroxychloroquine both belong to the quinolone family and share similar clinical indications and side effects, including retinal toxicity. Chloroquine-induced retinal toxicity was first described in 1959 and the retinal toxic effects of hydroxychloroquine were later described in 1967 3, 4. The mechanism of toxicity is unknown but is thought to be due to accumulation of the medication in the retinal pigment epithelium RPE, leading to subsequent RPE degeneration. 1 Because of this theorized accumulation, hydroxychloroquine toxicity can progress despite cessation of the medication. 1,2 Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Chloroquine eye toxicity Hydroxychloroquine toxicity - EyeWiki, Hydroxychloroquine Plaquenil Toxicity and. Dosage of chloroquine injection in adultsPlaquenil 200 mg tablet adalahAnti malaria pills chloroquineChloroquine phosphate solubility storage To reduce the incidence of chloroquine and hydroxychloroquine toxicity, health care providers HCP's that prescribe these medications and those that screen for ocular toxicity have developed clear dosing and screening protocols that have reduced the risk of end-stage disease; bull's eye maculopathy and central vision loss Level I. Chloroquine And Hydroxychloroquine Toxicity - StatPearls.. Retina Today - Imaging in Hydroxychloroquine Toxicity.. Chloroquine Side Effects Common, Severe, Long Term -. Of course the aim is avoid drug related retinal toxicity, which on ophthalmic examination, appears as the classic Bull’s eye change affecting the macula. Once retinal toxicity from hydroxychloroquine occurs, it is thought that the retinal changes are permanent and the disease can progress even if hydroxychloroquine is stopped for 1 to 3 years. Chloroquine and hydroxychloroquine can cause toxic retinopathy due to their binding of melanin in the retinal pigmented epithelium RPE as well as direct toxicity to retinal ganglion cells. Early findings include mottling of the RPE and blunted foveal reflex. As the retinopathy progresses, a bull's-eye maculopathy develops, as seen in these photos. In 1959, Hobbs established a definite link between long-term use of chloroquine and subsequent development of retinal pathology. In 1962, J Lawton Smith coined the term bull's eye maculopathy, regarded as the classic finding of macular toxicity. Many reports on chloroquine retinopathy exist.