The doctor said that given where I am right now (constant low level pain and light swelling of my hands and wrists but no joint damage showing up on xrays or the ultrasound), she gave me a choice of starting on either Plaquenil or Methotrexate. She went over some info on each drug and then gave me some time to think about which would be better for me. My largest concerns center around the side effects of each... Chloroquine itch mouse behavior Plaquenil heat Hydroxychloroquine eye symptoms Methotrexate Moderate Hydroxychloroquine may reduce the renal clearance of methotrexate; the exact mechanism of this interaction is unknown. The mean AUC of methotrexate was increased 52% and the mean Cmax was reduced 17% when a single dose of methotrexate was given with a dose of hydroxychloroquine 200 mg oral. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and. more Prescribed for Lyme Disease - Arthritis, Dermatomyositis, Malaria Prevention, Malaria, Rheumatoid Arthritis. I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. With Plaquenil, the possibility of permanent vision damage scares me. Plaquenil or methotrexate Hydroxychloroquine Side Effects, Dosage, Uses, and More, Compare Plaquenil vs Methotrexate - Chloroquine use and fluoroquinolone resistance dissertationHydroxychloroquine 200 mg nombre comercialPlaquenil false positive methadonePlaquenil oral usesPlaquenil blurry eyes Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Compare Methotrexate vs Plaquenil -. Methotrexate vs Plaquenil Comparison -. Methotrexate and hydroxychloroquine Rheumatoid Arthritis.. Hydroxychloroquine is a less commonly utilized disease modifying anti-rheumatic medication. It is an anti-malarial medication. There is no indication that Plaquenil requires discontinuation in the perioperative period. In Conclusion. The effect of disease modifying agents on surgical outcome is difficult to assess. Plaquenil hydroxychloroquine and Rheumatrex and Trexall methotrexate are used to treat rheumatoid arthritis. Plaquenil is also used to treat or prevent malaria, and to treat symptoms of discoid or systemic lupus erythematosus. Rheumatrex and Trexall are also used to treat some cancers and severe skin diseases such as severe psoriasis. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as.