If you take prescription medication, ask your doctor or pharmacist whether your medication interacts with grapefruit or other citrus products. You may need to eliminate grapefruit products from your diet. Tier for hydroxychloroquine Best time to take plaquenil Hello all, I just starting taking plaquenil and I was wondering what types of things I should avoid while taking it? Is it true that grapefruit is something I should avoid? Anything else that anyone knows will have a negative impact? Thanks for any feedback Hydroxychloroquine belongs to a group of medications known as anti-inflammatories and antimalarials. It is used alone or in combination with other anti-arthritic medications to treat rheumatoid arthritis. It helps to reduce pain, stiffness, and swelling in joints. Hydroxychloroquine is used to treat discoid lupus erythematosus DLE or systemic lupus erythematosus SLE or lupus. It is also used to treat acute and chronic rheumatoid arthritis. This medicine is available only with your doctor's prescription. Before using Plaquenil Alternatively, you can ask your doctor if there's a comparable medication you can take that doesn't interact with grapefruit. Simply taking your medication and grapefruit product at different times doesn't stop the interaction. Hydroxychloroquine and citrus Plaquenil questions -, Mint-Hydroxychloroquine - Uses, Side Effects, Interactions. Starting plaquenil during pregnancyChloroquine proguanil dosageAlternative to plaquenil for sjogren'sPlaquenil and shortness of breath Mar 21, 2007 Grapefruit juice, in large quantities 32 oz. or more per day, can inhibit the cytochrome P450 3A4 CYP3A4 enzyme and increase blood levels of drugs metabolized by this pathway, such as certain statin drugs. 1,2 Note that this interaction applies to grapefruit juice, not the whole fruit itself. Food–Drug Interactions. Plaquenil Advanced Patient Information -. Plaquenil & other drug interactions ? Lupus Forums at The.. Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. The genus Citrus and related genera Fortunella, Poncirus, Eremocitrus and Microcitrus belong to the angiosperm subfamily Aurantioideae of the Rutaceae family, which is widely distributed across. If grapefruit juice is not mentioned, ask the pharmacist if you can safely drink it. Make a list of all your medications, including prescription drugs and over-the-counter drugs. Review the list with your healthcare providers and pharmacist to look for possible drug interactions.