Chloroquine glutathione synthase

Discussion in 'Canadian Drug' started by darksnik, 11-Mar-2020.

  1. domenchip Moderator

    Chloroquine glutathione synthase


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Glutathione is called an antioxidant because of its role in protecting cells from the damaging effects of these unstable molecules. Mutations in the GSS gene prevent cells from making adequate levels of glutathione, leading to the signs and symptoms of glutathione synthetase deficiency. Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. Oct 01, 2018 The dosage of Chloroquine phosphate is often expressed in terms of equivalent Chloroquine base. Each 500 mg tablet of Chloroquine phosphate contains the equivalent of 300 mg Chloroquine base. In infants and children the dosage is preferably calculated by body weight.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine glutathione synthase

    BRENDA - Information on EC 6.3.2.3 - glutathione synthase, Chloroquine - Wikipedia

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  5. Glutathione synthetase deficiency GSD is a rare autosomal recessive metabolic disorder that prevents the production of glutathione. Glutathione helps prevent damage to cells by neutralizing harmful molecules generated during energy production.

    • Glutathione synthetase deficiency - Wikipedia.
    • Chloroquine - FDA prescribing information, side effects and uses.
    • Glutathione - an overview ScienceDirect Topics.

    Search results for GSH at Sigma-Aldrich. Compare Products Select up to 4 products. *Please select more than one item to compare In Arabidopsis thaliana, biosynthesis of the essential thiol antioxidant, glutathione GSH, is plastid-regulated, but many GSH functions, including heavy metal detoxification and plant defense activation, depend on cytosolic GSH. This finding suggests that plastid and cytosol thiol pools are closely integrated and we show that in Arabidopsis this integration requires a family of three. Chloroquine is a lysosomotropic weak base, which in the monoprotonated form diffuses into the lysosome, where it becomes diprotonated and becomes trapped. Protonated chloroquine then changes the lysosomal pH, thereby inhibiting autophagic degradation in the lysosomes.

     
  6. oSa New Member

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Chloroquine - FDA prescribing information, side effects. Chloroquine Oral Uses, Side Effects, Interactions, Pictures. Chloroquine diphosphate salt powder or crystals, 98.5-101.
     
  7. Growle Well-Known Member

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