Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Dosage of plaquenil for rheumatoid arthritis Plaquenil toxicity treatment Macrobid and hydroxy chloroquine interactions Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. The only drugs I have ever had any relief from have been cellcept and methotrexate, yet I seem to suffer terrible side effects with both. A few weeks ago I noticed really bad fluid retention in my ankles which then spread all over my body until I practically doubled in size with fluid. More recent NSAIDs like Celebrex® or Arcoxia® may have a lower risk of gastrointestinal side effects. To minimise side effects, NSAIDs should be taken only as directed. NSAIDs are also known to cause increased blood pressure and fluid retention and may impair kidney function in people with lupus. Hydroxychloroquine may also be used for purposes not listed in this medication guide. Hydroxychloroquine is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil side effects fluid retention Hydroxychloroquine Sulfate Fluid Retention Reports - DrugInformer, Cellcept and fluid retention Lupus Forums at The Lupus Site Hydroxychloroquine and methotrexateChloroquine phosphate brand nameChloroquine dose for childPlaquenil and shinglesPlaquenil red spots on chest I have mild Raynaud's, arthritis / joint pain 1st symptom, severe fatigue OMG off the charts some days and horrible fluid retention as well as the puffy hands/fingers at times. I was started on 200 mg BID so a 400 mg dose daily. Plaquenil side effects question In Scleroderma Foundation. Hello everyone. For those of you that take. Plaquenil side effects - Scleroderma - Inspire. Lupus and medication - Better Health Channel. Plaquenil And Mood Swings? - Sclero Forums. View detailed reports from patients taking plaquenil who experienced fluid retention. Reports are from official medical reports as well as online extractions from user reviews and forum discussions. Druginformer Identified Side Effects Condition aggravated, Dyspepsia, Fluid retention. hydroxychloroquine sulfate related fluid retention; Very rare to have any major side effects. Plaquenil Side Effects. Fluid retention Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.