Chloroquine-induced em

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  1. SubaRUS Well-Known Member

    Chloroquine-induced em

    The RYR2 ryanodine receptor isoform is the major cellular mediator of calcium-induced calcium release (CICR) in animal cells. In skeletal muscle, activation of ryanodine receptors occurs via a physical coupling to the dihydropyridine receptor (a voltage-dependent, L-type calcium channel), whereas, in cardiac muscle, the primary mechanism of activation is calcium-induced calcium release, which causes calcium outflow from the sarcoplasmic reticulum.

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    On day 3 of chloroquine therapy, she developed localized brisk bullous eruptions in the irradiated area, which developed into a patch of fulminant moist desquamation. After radiotherapy was withheld for 1 week, the moist desquamation had almost healed. Chloroquine seemed to be the most probable cause for the adverse event. Psychiatric Apr 09, 1977 1. Br Med J. 1977 Apr 9;16066945-6. Chloroquine induced involuntary movements. Umez-Eronini EM, Eronini EA. PMCID PMC1605758 PMID 851793 Chloroquine-induced pruritus remains one of the most common side-effects in the use of chloroquine in the prophylaxis and treatment of uncomplicated malaria before the advent of artemisinin-based combination therapies.

    Ry Rs are especially important in neurons and muscle cells. It has been shown that calcium release from a number of ryanodine receptors in a ryanodine receptor cluster results in a spatiotemporally restricted rise in cytosolic calcium that can be visualised as a calcium spark.

    Chloroquine-induced em

    Chloroquine-induced pruritus, Chloroquine induced involuntary movements.

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  4. In one study restrictive cardiomyopathy induced by chloroquine was diagnosed by non-invasive methods jugular venous pulse and cross-sectional echocardiography and skeletal muscle biopsy, revealing curvilinear and myelinoid bodies.2 Five weeks after discontinuation of chloroquine, the patient expired and post-mortem EM of the cardiac tissue revealed myelinoid and curvilinear bodies.

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    Electron microscopy demonstrates CQ-induced mitochondrial cristae damage, which leads to mitochondrial membrane depolarization with a significant reduction in the activity of cytochrome c oxidase and accumulation of superoxide and double-stranded DNA breaks. The chloroquine-induced increase in the expression levels of p53 target genes was also observed in other cell lines expressing wtp53 such as HCT116 and G168 Fig. 3B, right panel and data not shown. In contrast, chloroquine treatment did not induce p53 target genes in glioma lines lacking functional p53 Fig. Antidepressants of the tricyclic and monoamine oxidase inhibitor classes can induce mania in patients with preexisting bipolar affective disorder. 1 Drugs that are probably capable of inducing mania, but for which the evidence is less scientifically secure, include other dopaminergic antiparkinsonian drugs, thyroxine, iproniazid and isoniazid, sympathomimetic drugs, baclofen, corticosteroids, 5-dehydroepiandrosterone, alprazolam, ciprofloxacin, captopril, amphetamine, angiotensin convertase.

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