Method of action of chloroquine

Discussion in 'Canada Drugs' started by endalanix, 17-Mar-2020.

  1. Quietm Moderator

    Method of action of chloroquine

    Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. This medication is used to kill the malaria parasites living inside red blood cells.

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    The mode of action of chloroquine and related malarial schizontocides. Abstract. Use of fast-acting blood schizontocidal drugs such as chloroqune, amodiaquine, mepacrine or quinine, is essential for the treatment of acute malaria infections. Another method to prepare chloroquine 3 involves reaction of 83 with methyl acrylate to get via 98 and 99 the adduct 100, which is converted into 7-chloro-1,2,3,4-tetrahydroquinoline-4-one 103. Reaction of 103 with novaldiamine 92 under dehydrogenating conditions gives chloroquine in about 25% overall yield 133 3. Chloroquine enters the red blood cell, inhibiting the parasite cell and digestive vacuole by simple diffusion. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion.

    Both drugs may be needed for a complete cure and to prevent the return of infection (relapse). In some cases, you may need to take a different medication (such as primaquine) to kill the malaria parasites living in other body tissues.

    Method of action of chloroquine

    Chloroquine - FDA prescribing information, side effects and uses, Chloroquine - an overview ScienceDirect Topics

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  6. Quinine probably _____ does/does not utilise other methods of action. Nausea, vomiting, tinnitus, hearing loss, headache, disturbed vision, diarrhoea, vertigo, hypoglycaemia, Blackwater fever Side effects of quinine include

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    Chloroquine has been sporadically used in treating SARS-CoV-2 infection. Hydroxychloroquine shares the same mechanism of action as chloroquine, but its more tolerable safety profile makes it the preferred drug to treat malaria and autoimmune conditions. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Chloroquine is thought to exert its antimalarial effect by preventing the polymerization of toxic heme released during proteolysis of hemoglobin in the Plasmodium digestive vacuole. The mechanism of this blockade has not been established. We incubated cultured parasites with subinhibitory doses of 3Hchloroquine and 3H quinidine.

  7. poussin Well-Known Member

    In some cases, they may not be available in every strength or form as the brand-name drug. Compare Plaquenil vs Chloroquine - Hydroxychloroquine Prices, Coupons & Savings Tips - GoodRx Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus
  8. starla Moderator

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Hydroxychloroquine Uses, Dosage & Side Effects - Plaquenil hydroxychloroquine sulfate dosing, indications. Hydroxychloroquine - Side Effects, Dosage, Interactions - Drugs.
  9. nigilist Well-Known Member

    Sjogren's syndrome - Diagnosis and treatment - Mayo Clinic Yeast infections in the mouth should be treated with antifungal medications. Treat systemwide symptoms. Hydroxychloroquine Plaquenil, a drug designed to treat malaria, is often helpful in treating Sjogren's syndrome. Drugs that suppress the immune system, such as methotrexate Trexall, also might be prescribed.

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