Chloroquine oral pigmentation

Discussion in 'Canada Drugs' started by Romeo.rzn, 19-Mar-2020.

  1. varus XenForo Moderator

    Chloroquine oral pigmentation


    Pigmentation can be either normal or abnormal discoloration of oral mucous membrane. The purpose of this review mainly focuses on the main oral pigmented lesions, in order to help the clinicians establish a better approach towards the patients with pigmented oral lesions and to provide thorough knowledge regarding such lesions for patient reassurance, early definitive diagnosis and prompt treatment.

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    Quizzn is a young service that bears only one goal - to make the learning process as enjoyable, social, and easy as possible. It is a free application that has the ability to connect people that are eager to learn, share knowledge and just have fun. Oral melanoma can present as a macule, a plaque or a mass. It can be well-circumscribed or irregular, and focally or diffusely pigmented, and even lacking pigment amelanotic. Occasional tumors may exhibit multifocal pigmentation due to the presence of melanotic and amelanotic areas within the same lesion. Chloroquine is rapidly and almost completely absorbed from the bowel following oral administration. Peak plasma concentrations of chloroquine are reached within 4–12 hours, but it takes 4–6 weeks for plasma concentrations to stabilise; therefore, it will take 2–3 months to see a therapeutic effect.

    Pigmented lesions affecting the skin were not included in our review. Relevant data concerning oral pigmented lesions, clinical features and the possibility of malignant transformation of such lesions were reviewed thoroughly from pubmed literature published in English.

    Chloroquine oral pigmentation

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  4. Antimalarial drug–induced oral hyperpigmentation is uncommon and is reported to occur on the hard palate, gingiva, lips, and buccal mucosa.15, 47 In a retrospective study, pigmentation of the buccal mucosa or the hard palate was seen in 10 patients 5% using chloroquine, but none in hydroxychloroquine, 50 and there are rare case reports of.

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    Given the history of long-term chloroquine use, the top clinical working diagnosis was drug-induced oral pigmentation caused by chloroquine phosphate. To confirm this, and rule out the possibility of melanoma, a surgical evaluation was requested and the patient then underwent an incisional biopsy Fig. 2. Jul 30, 2019 Applies to chloroquine compounding powder, injectable solution, oral tablet. Ocular. Maculopathy and macular degeneration may be irreversible. Irreversible retinal damage has been reported in patients receiving long-term or high-dose 4-aminoquinoline therapy. Retinopathy has been reported as dose related. Aug 30, 2011 Given the history of long-term chloroquine use, the top clinical working diagnosis was drug-induced oral pigmentation caused by chloroquine phosphate. To confirm this, and rule out the possibility of melanoma, a surgical evaluation was requested and the patient then underwent an incisional biopsy Fig. 2.

     
  5. Autophagy is an important cell recycling program responsible for the clearance of damaged or long-lived proteins and organelles. Chloroquine, an autophagy inhibitor, potentiates the radiosensitivity. CST - Chloroquine Lysosomotropism depends on glucose a chloroquine resistance mechanism.
     
  6. ValD Well-Known Member

    Pause the Plaquenil? Dr. Marmor’s research team also recommended that screening should be performed within the first year of initiating therapy, and then annually after five years of Plaquenil use. The risk for retinal toxicity begins once the patient has used Plaquenil for five to seven years and/or has taken a cumulative dose of more than 1,000g.

    Plaquenil Toxicity - OCTMD