Synthesis of chloroquine from 4 7-dichloroquinoline

Discussion in 'Canada Drugs Online' started by Wildmudiott, 08-Mar-2020.

  1. Maximys Guest

    Synthesis of chloroquine from 4 7-dichloroquinoline


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    Dichloroquinoline 86-98-6 route of synthesis, 4,7-Dichloroquinoline chemical synthesis methods, 4,7-Dichloroquinoline synthetic routes ect. +86-400-6021-666 [email protected] The present invention provides a process for the preparation of hydroxychloroquine by the reaction of 4,7-dichloroquinoline with N'-ethyl-N'-β-hydroxyethyl-1,4-pentadiamine under high pressure. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite.

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    Synthesis of chloroquine from 4 7-dichloroquinoline

    Chloroquine - ScienceDirect, WO2010027150A2 - New preparation of hydroxychloroquine.

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  5. Synthesis of New 4-Aminoquinolines and Evaluation of Their In Vitro Activity against Chloroquine-Sensitive. 4,7-dichloroquinoline 11in N-methyl-2-pyrrolidone.

    • Synthesis of New 4-Aminoquinolines and Evaluation of Their In..
    • Chloroquine C18H26ClN3 - PubChem.
    • Synthesis and Antimalarial Activities of Cyclen 4..

    The synthesis of various 4-aminoquinoline antimalarials may be achieved by nucleophilic reaction of 91 with desired amines. Scheme 2 outlines the preparation of chloroquine 3 and amodiaquine 8 starting from 4,7-dichloroquinoline 91 134–136. Synthesis of 4,7-Dichloroquinoline CAS NO. which is also known as, 4,7-dichloro-, could be produced through the following synthetic routes. A. Ethyl α-carbethoxy-β-m-chloroanilinoacrylate. A few boiling chips are added to a mixture of 127.5 g. 1.0 mole of m-chloroaniline and 233 g. Synthesis of New Chloroquine Derivatives as Antimalarial Agents. 4,7-dichloroquinoline 25.35 g, 0. 128 mol and 3-aminopro-. Synthesis of new Chloroquine Derivatives 541.

     
  6. brthrough Well-Known Member

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Hydroxychloroquine Plaquenil Side Effects & Dosage for. Hydroxychloroquine Oral Uses, Side Effects, Interactions. RA and Hydroxychloroquine How Effective is it for Rheumatoid.
     
  7. enjoy XenForo Moderator

    Treatment of Malaria Guidelines for Clinicians United States In addition, any of the regimens listed for the treatment of chloroquine-resistant malaria may be used for the treatment of chloroquine-sensitive. P. falciparum. malaria. Prompt initiation of an effective regimen is vitally important, so using any one of the effective regimens that is readily available would be the preferred strategy.

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