I can say that I am not having pain like I used to, and I am so grateful for that! I don't know if this is just the RA in full swing, or if it is a side effect of the Plaquenil. I have been running a low-grade fever (around 99.8) for about a week and a half now. How does plaquenil treat lupus Efectos de hydroxychloroquine Tab hydroxychloroquine 200 mg Is a side effect of hydroxychloroquine making my cheeks flush Jun 21, 2015 Hydroxychloroquine Plaquenil and generics can itself cause fatigue in some users, it can interrupt sleep patterns especially by causing more vivid dreams which in turn makes one more tired. The drug can also lower blood counts red cell, white cells and others too which in turn can cause fatigue. May 25, 2010 Hi! I think Plaquenil is the cause of my extreme fatigue too. I am not anemic at this time and I get exhausted just trying to get through the day. I have also been on Plaquenil about three months. All of my arthritis swelling and pain are gone, but the fatigue will not let up! Hope things change for you. Hydroxychloroquine is the immunomodulatory drug most frequently used for primary Sjögren syndrome, 7 usually prescribed for patients with fatigue, arthralgia, and myalgia 8-10 rather than severe systemic manifestations. The latter symptoms are treated with corticosteroids and azathioprine, cyclophosphamide, mycophenolate mofetil, or rituximab. My normal body temperature is low, around 97.5, so I don't know if 99.8 would be considered a fever. It comes & goes and I can tell when it is up because I feel hot. Plaquenil et fatigue Plaquenil hydroxychloroquine sulfate dose, indications., Is extreme fatigue a side effect of Plaquenil? Hydroxychloroquine decrease inflammation I've been on Plaquenil now for three months and its starting to help with the pain although I have diarrhoea every day but it's manageable. But I'm really struggling with fatigue now - worse than its ever been. Don't know whether its the RA itself or my body reacting to Plaquenil but I can't seem to do anything without being really really tired. Is extreme fatigue a side effect of Plaquenil - NRAS. Hydroxychloroquine for Sjögren Syndrome Symptoms - The JAMA Network. Hydroxychloroquine Plaquenil Success, Reviews and Side Effects. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Feb 19, 2020 Plaquenil Hydroxychloroquine may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Fatigue The causes of fatigue in Sjogren’s syndrome are numerous. The only strong therapeutic recommendation for fatigue in Sjogren’s syndrome is exercise. Hydroxychloroquine is the most widely prescribed treatment in the U. S. to manage fatigue in Sjogren’s syndrome, but this practice is largely made based on clinical experience.