She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. Chloroquine protein synthesis Chloroquine phosphate injection dosage Hydroxychloroquine human antichimeric antibodies SD-OCT can show signs of early HCQ retinopathy before unmistakable parafoveal EZ disruption develops, and these signs may assist in earlier detection of HCQ toxicity. Early detection is critical because both structural and functional progression may occur after the drug is discontinued. Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus eye toxicity limits long-term use of the drugs. Hydroxychloroquine HCQ retinopathy can result in permanent vision loss. In early stages of HCQ retinopathy, patients are usually asymptomatic with preservation of visual acuity. Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Oct hydroxychloroquine retinopathy RCOphth guideline Hydroxychloroquine and Chloroquine., Chloroquine retinopathy - Wikipedia Taking plaquenil twice a dayPlaquenil and allergy medication interactionsPlaquenil pulmonary side effectsPlaquenil and tremblingHow long for plaquenil rash to go away Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Hydroxychloroquine retinopathy A review of imaging. Hydroxychloroquine Retinopathy with SD-OCT Changes and.. Purpose. To investigate the distribution of outer retinal changes in hydroxychloroquine HCQ retinopathy and explore optical coherence tomography OCT protocols to maximize the sensitivity of HCQ retinopathy detection in Asian patients. Spectral domain optical coherence tomography SD OCT images, red-free photos, and fundus autofluorescence FAF demonstrate a spectrum of findings seen with different stages of hydroxychloroquine retinopathy. Note the increased signal of choroidal vessels. Hydroxychloroquine HCQ; Plaquenil is used increasingly in the management of a variety of autoimmune disorders, with well established roles in dermatology and rheumatology and emerging roles in.