Hydroxychloroquine weight based dosing

Discussion in 'Aralen' started by npoatom, 05-Mar-2020.

  1. xaxa Guest

    Hydroxychloroquine weight based dosing


    Most importantly, you help support continued development of this site. The majority of cases of retinotoxicity have occurred in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine (Plaquenil). This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day (200 bid).

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    The risk increases with a higher dose and longer therapy. Vision risks. Hydroxychloroquine is dosed according to body weight. The American Academy of Ophthalmology AAO currently defines an overdose of hydroxychloroquine as more than 5.0 milligrams mg per kilogram kg of body weight 1 kg equals 2.2 pounds or more than 400 mg a day. Feb 19, 2020 Urine hydroxychloroquine levels were still detectable after 3 months with approximately 10% of the dose excreted was parent drug. Results following a single dose of a 200 mg tablet versus i.v. infusion 155 mg, demonstrated a halflife of about 40 days and a large volume of distribution. Regarding the dosing of hydroxychloroquine, we advocate the use of a weight-based dosing regimen with a cap at 400 mg per day, except in the case of renal insufficiency, when the dose should be.

    It now solely uses real body weight (rather than ideal body weight) based on new recommendations from a 2014 study (1). Disclaimer: This tool is designed to help eye care professionals better understand the risk the of retinotoxicity from hydroxychloroquine. Please note: This calculator was modified in 9/2015.

    Hydroxychloroquine weight based dosing

    Hydroxychloroquine - Side Effects, Dosage, Interactions., Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.

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  4. There were no differences in hydroxychloroquine levels when both height and ideal body weight were compared across the different blood concentrations. This suggests that we are correctly dosing patients based on actual rather than ideal body weight not exceeding a dose of 400 mg per day and indicated that dosing based on height is unnecessary.

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    The current American Academy of Ophthalmology AAO guidelines, published in 2016, recommend a maximum daily hydroxychloroquine dose of ≤5.0 mg/kg of real weight. These guidelines were established to minimize the likelihood of permanent vision loss related to hydroxychloroquine retinopathy. The dosage is based on body weight. 6.5 mg/kg maximum dose 400 mg should be given on the same day each week starting 2 weeks before exposure to malaria. An audit of 100 patients seen at any of nine Canadian rheumatology clinics during early 2016 showed that 30% of patients were not on appropriate weight-based hydroxychloroquine dosages, and 13% of patients on the drug had not received a baseline retinal assessment during their first year.

     
  5. tRANcIr Moderator

    Diagnosing lupus is difficult because signs and symptoms vary considerably from person to person. Hydroxychloroquine - LiverTox - NCBI Bookshelf Taking Hydroxychloroquine for RA or Lupus Can Reduce Heart. Drug spotlight on hydroxychloroquine Lupus Foundation of.
     
  6. avrora User

    Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Chloroquine Oral Route Before Using - Mayo Clinic Plaquenil Oral Uses, Side Effects, Interactions, Pictures.
     
  7. Registr Moderator

    Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Side effects, drug interactions, pregnancy safety information, and dosage information should be reviewed prior to taking this medication.

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