Most importantly, you help support continued development of this site. The majority of cases of retinotoxicity have occurred in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine (Plaquenil). This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day (200 bid). Plaquenil eval icd 10 Chloroquine brands Chloroquine autophagic flux The risk increases with a higher dose and longer therapy. Vision risks. Hydroxychloroquine is dosed according to body weight. The American Academy of Ophthalmology AAO currently defines an overdose of hydroxychloroquine as more than 5.0 milligrams mg per kilogram kg of body weight 1 kg equals 2.2 pounds or more than 400 mg a day. Feb 19, 2020 Urine hydroxychloroquine levels were still detectable after 3 months with approximately 10% of the dose excreted was parent drug. Results following a single dose of a 200 mg tablet versus i.v. infusion 155 mg, demonstrated a halflife of about 40 days and a large volume of distribution. Regarding the dosing of hydroxychloroquine, we advocate the use of a weight-based dosing regimen with a cap at 400 mg per day, except in the case of renal insufficiency, when the dose should be. It now solely uses real body weight (rather than ideal body weight) based on new recommendations from a 2014 study (1). Disclaimer: This tool is designed to help eye care professionals better understand the risk the of retinotoxicity from hydroxychloroquine. Please note: This calculator was modified in 9/2015. Hydroxychloroquine weight based dosing Hydroxychloroquine - Side Effects, Dosage, Interactions., Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Hydroxychloroquine sulfate highChloroquine 200 mg There were no differences in hydroxychloroquine levels when both height and ideal body weight were compared across the different blood concentrations. This suggests that we are correctly dosing patients based on actual rather than ideal body weight not exceeding a dose of 400 mg per day and indicated that dosing based on height is unnecessary. Hydroxychloroquine Blood Levels in SLE Clarifying dosing.. RheumNow Hydroxychloroquine Blood Levels in SLE MedPage.. Medicines for the Prevention of Malaria While Traveling.. The current American Academy of Ophthalmology AAO guidelines, published in 2016, recommend a maximum daily hydroxychloroquine dose of ≤5.0 mg/kg of real weight. These guidelines were established to minimize the likelihood of permanent vision loss related to hydroxychloroquine retinopathy. The dosage is based on body weight. 6.5 mg/kg maximum dose 400 mg should be given on the same day each week starting 2 weeks before exposure to malaria. An audit of 100 patients seen at any of nine Canadian rheumatology clinics during early 2016 showed that 30% of patients were not on appropriate weight-based hydroxychloroquine dosages, and 13% of patients on the drug had not received a baseline retinal assessment during their first year.